Birth Defects Profile

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Birth Defects Profile, Alachua County, Florida
Indicator	Year(s)	County Count	County Rate* (99% Cl)	State Count	State Rate* (99% Cl)
Cardiovascular ConditionsCardiovascular Conditions
Aortic valve stenosisAortic valve stenosis	2012-2016	<5	N/A	139	1.3 (1.1-1.5)
Atrial septal defectAtrial septal defect	2012-2016	94	65.8 (52.5-79.1)	12,519	114.9 (112.9-116.9)
Atrioventricular septal defect (Endocardial cushion defect)	2012-2016	<5	N/A	402	3.7 (3.3-4.1)
Coarctation of the aortaCoarctation of the aorta	2012-2016	7	4.9 (2.0-10.1)	683	6.3 (5.8-6.7)
Common truncus (Truncus arteriosus)Common truncus (Truncus arteriosus)	2012-2016	<5	N/A	75	0.7 (0.5-0.8)
Critical Congenital Heart DefectsCritical Congenital Heart Defects	2012-2016	31	21.7 (14.1-29.3)	2,190	20.1 (19.3-20.9)
Double outlet right ventricleDouble outlet right ventricle	2012-2016	<5	N/A	235	2.2 (1.9-2.4)
Ebstein anomalyEbstein anomaly	2012-2016	<5	N/A	74	0.7 (0.5-0.8)
Hypoplastic left heart syndromeHypoplastic left heart syndrome	2012-2016	<5	N/A	368	3.4 (3.0-3.7)
Interrupted aortic archInterrupted aortic arch	2012-2016	7	4.9 (2.0-10.1)	251	2.3 (2.0-2.6)
Pulmonary valve atresia and stenosisPulmonary valve atresia and stenosis	2012-2016	8	5.6 (2.4-11.0)	1,030	9.5 (8.9-10.0)
Single ventricleSingle ventricle	2012-2016	<5	N/A	149	1.4 (1.2-1.6)
Tetralogy of FallotTetralogy of Fallot	2012-2016	8	5.6 (2.4-11.0)	527	4.8 (4.4-5.3)
Total anomalous pulmonary venous returnTotal anomalous pulmonary venous return	2012-2016	<5	N/A	77	0.7 (0.6-0.9)
Transposition of the great arteries (TGA)	2012-2016	<5	N/A	268	2.5 (2.2-2.8)
Tricuspid valve atresia and stenosisTricuspid valve atresia and stenosis	2012-2016	<5	N/A	97	0.9 (0.7-1.1)
Ventricular septal defectVentricular septal defect	2012-2016	74	51.8 (40.0-63.6)	6,748	61.9 (60.5-63.4)
Central Nervous System ConditionsCentral Nervous System Conditions
AnencephalusAnencephalus	2012-2016	<5	N/A	96	0.9 (0.7-1.1)
EncephaloceleEncephalocele	2012-2016	<5	N/A	70	0.6 (0.5-0.8)
HoloprosencephalyHoloprosencephaly	2012-2016	8	5.6 (2.4-11.0)	395	3.6 (3.3-4.0)
Spina bifida without anencephalusSpina bifida without anencephalus	2012-2016	<5	N/A	270	2.5 (2.2-2.8)
Chromosomal ConditionsChromosomal Conditions
Deletion 22q11.2Deletion 22q11.2	2012-2016	<5	N/A	23	0.2 (0.1-0.3)
Trisomy 13Trisomy 13	2012-2016	<5	N/A	106	1.0 (0.8-1.2)
Trisomy 18Trisomy 18	2012-2016	<5	N/A	205	1.9 (1.6-2.1)
Trisomy 21 (Down syndrome)Trisomy 21 (Down syndrome)	2012-2016	17	11.9 (6.9-19.1)	1,384	12.7 (12.0-13.4)
Turner syndromeTurner syndrome	2012-2016	<5	N/A	93	1.8 (1.4-2.1)
Ear and Eye ConditionsEar and Eye Conditions
Anophthalmia/microphthalmiaAnophthalmia/microphthalmia	2012-2016	<5	N/A	124	1.1 (0.9-1.3)
Anotia/microtiaAnotia/microtia	2012-2016	<5	N/A	116	1.1 (0.9-1.3)
Congenital cataractCongenital cataract	2012-2016	<5	N/A	126	1.2 (1.0-1.4)
Gastrointestinal ConditionsGastrointestinal Conditions
Biliary atresiaBiliary atresia	2012-2016	<5	N/A	146	1.3 (1.1-1.6)
Esophageal atresia/tracheoesophageal fistula	2012-2016	6	4.2 (1.5-9.1)	252	2.3 (2.0-2.6)
Rectal and large intestinal atresia/stenosis	2012-2016	12	8.4 (4.3-14.7)	435	4.0 (3.6-4.4)
Small intestinal atresia/stenosisSmall intestinal atresia/stenosis	2012-2016	7	4.9 (2.0-10.1)	456	4.2 (3.8-4.6)
Genitourinary ConditionsGenitourinary Conditions
Bladder exstrophyBladder exstrophy	2012-2016	<5	N/A	23	0.2 (0.1-0.3)
Cloacal exstrophyCloacal exstrophy	2012-2016	11	7.7 (3.8-13.8)	508	4.7 (4.3-5.1)
Congenital posterior urethral valvesCongenital posterior urethral valves	2012-2016	<5	N/A	123	1.1 (0.9-1.3)
HypospadiasHypospadias	2012-2016	49	67.5 (48.6-86.3)	4,000	71.7 (69.4-73.9)
Renal agenesis/hypoplasiaRenal agenesis/hypoplasia	2012-2016	6	4.2 (1.5-9.1)	569	5.2 (4.8-5.7)
Musculoskeletal ConditionsMusculoskeletal Conditions
ClubfootClubfoot	2012-2016	26	18.2 (11.9-26.7)	1,630	15.0 (14.2-15.7)
CraniosynostosisCraniosynostosis	2012-2016	<5	N/A	182	1.7 (1.4-1.9)
Diaphragmatic herniaDiaphragmatic hernia	2012-2016	7	4.9 (2.0-10.1)	316	2.9 (2.6-3.2)
GastroschisisGastroschisis	2012-2016	<5	N/A	458	4.2 (3.8-4.6)
Limb deficiencies (reduction defects)Limb deficiencies (reduction defects)	2012-2016	6	4.2 (1.5-9.1)	382	3.5 (3.2-3.9)
OmphaloceleOmphalocele	2012-2016	<5	N/A	233	2.1 (1.9-2.4)
Orofacial ConditionsOrofacial Conditions
Choanal atresiaChoanal atresia	2012-2016	<5	N/A	203	1.9 (1.6-2.1)
Cleft lip aloneCleft lip alone	2012-2016	<5	N/A	258	2.4 (2.1-2.7)
Cleft lip with cleft palateCleft lip with cleft palate	2012-2016	11	7.7 (3.8-13.8)	566	5.2 (4.8-5.6)
Cleft palate aloneCleft palate alone	2012-2016	10	7.0 (3.4-12.9)	559	5.1 (4.7-5.6)
Total Birth DefectsTotal Birth Defects
Total Birth DefectsTotal Birth Defects	2012-2016	303	212.1 (188.2-236.0)	27,242	250.0 (247.0-253.0)

Data Note(s):

Florida Birth Defects Profile Definitions

Florida Birth Defects Registry: 2009-2013 birth defects data have been revised as of September 26, 2016.

Results have been suppressed when the estimated case count is between 0 and 4.

*Rate = Number of cases per 10,000 live births.

95% CI = The rate is accompanied by the 95% confidence interval.

99% CI = The rate is accompanied by the 99% confidence interval.

Beginning with the 2010-2014 data, the rate of each birth defect or birth defect grouping is provided along with 95% confidence intervals. As suggested by the National Birth Defects Prevention Network’s Guidelines for Conducting Birth Defects Surveillance, for small numbers of cases (which we have defined as 30 or fewer), the Poisson distribution was used to generate 95% confidence intervals. When the case count was greater than thirty, we calculated 95% confidence intervals using the normal approximation.